Scientist, AAV Analytical Dev., Analytical Chemistry

Posted 07 July 2021
SalaryUp to £0.00 per annum
LocationThousand Oaks, Ventura, California
Job type Permanent
DisciplineLife Sciences
Contact NameBecky Krage

Job description

Scientist - AAV Analytical Development - Analytical Chemistry

We are a fully integrated AAV engineering and gene therapy company poised to create
the next generation of innovative genetic therapies with life-changing potential for
patients with grievous unmet medical needs.

We leverage our proprietary high-throughput, data science driven AAV engineering
platform to create viral vectors with cell-type and tissue level specificity, overcoming
many of the biological limitations of early gene therapy efforts. Combined with our inhouse
preclinical and manufacturing expertise, we are positioned to create the next
generation of AAV delivered gene therapies, dramatically changing the lives of patients.

We are founded on the idea that diverse backgrounds and skill sets combine to create
an environment that stimulates innovation and creativity, enabling us to grow into a
leader in the AAV gene therapy space. Our leadership team is comprised of the scientific
founders that developed the underlying intellectual property, and experienced industry
veterans with a track record for brining transformative drugs to market. Together with
our partners, we will combine next generation engineered capsids with cutting edge
gene editing and delivery modalities to bring novel medicines to patients that need
them. Our research and development labs, offices, and manufacturing space are located
in Newbury Park, near the Amgen campus.

Scientist- AAV Analytical Development- Analytical Chemistry

We are looking for a motivated scientist to join the AAV analytical development team.
The goal of this position is to lead the development of biophysical characterization
methods for characterizing AAV vectors. Under the guidance of senior leadership, you
will design and execute experiments focusing on the development of assays for the
analysis of intact capids, capsid proteins, vector genomes, and process impurities. A
successful candidate will have strong technical and organizational skills and work
seamlessly with a team. Laboratory activities will constitute approximately 75% of the

Major Responsibilities

  • Lead analytical development efforts with novel CE and/or LC assays for quantifyingand characterizing capsid protein and process related impurities
  • Support novel intact virus assay development including but not limited to aggregation, charge variant analysis, and vector stability
  • Optimize analytical methods to increase accuracy and throughput
  • Test vectors from various stages of development and production to support process development and research activities
  • Work with external partners to evaluate new technologies
  • Maintain accurate and detailed laboratory notes
  • Contribute to the maintenance and upkeep of lab operations
  • Author technical materials, procedures, protocols, and reports
  • Plan, schedule, and execute on experimental designs in collaboration with senior leadership
  • Conduct troubleshooting experiments
  • Perform additional tasks as assigned

Essential Requirements:

  • B.S. or M.S. with a minimum of 3-8 years or PhD with 0-2 years relevant experience in a biotechnology, pharmaceutical, or academic setting
  • Experience with capillary electrophoresis (CE) and/or liquid chromatography (LC) assay development required
  • Experience with dynamic light scattering (DLS), mass spectrometry (MS), gel electrophoresis, asymmetric flow-field flow fractionation (AF4) and nucleic acid analysis is strongly preferred
  • Knowledge of assay design for both quantification and limit of detection methods
  • Experience developing and optimizing protocols or standard operating procedures strongly preferred
  • Excellent organizational and collaborative skills, with the ability to design and troubleshoot experiments with minimal supervision or as part of a group.
  • Prior experience working with gene therapy vectors strongly preferred
  • Must be eligible to work in the U.S.